Drug interactions
Calcium + Methyclothiazide
Severity: Moderate
Calcium and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, so adding calcium supplements can raise serum calcium. Hypercalcemia and, with alkali co-ingestion, milk-alkali syndrome may occur, especially with high calcium doses or renal impairment.
What this interaction means in plain words
Calcium and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides increase distal tubular calcium reabsorption, decreasing renal calcium clearance.
What to do
Monitor serum calcium periodically, particularly when starting or increasing calcium or vitamin D. Reduce the calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Methyclothiazide?
MediHelp rates the interaction as moderate. Calcium and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, so adding calcium supplements can raise serum calcium. Hypercalcemia and, with alkali co-ingestion, milk-alkali syndrome may occur, especially with high calcium doses or renal impairment.
How serious is the interaction between Calcium and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, particularly when starting or increasing calcium or vitamin D. Reduce the calcium dose if hypercalcemia develops.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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