Drug interactions
Calcium + Mycophenolate
Severity: Moderate
Calcium and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing divalent cations may reduce mycophenolate exposure, with the effect most clearly documented for magnesium and aluminum. Calcium carbonate is likely to have a smaller effect, but reduced immunosuppression is a concern in transplant recipients.
What this interaction means in plain words
Calcium and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced absorption of mycophenolate through higher gastric pH and cation binding.
What to do
Separate doses by at least 2 hours and monitor for signs of rejection or mycophenolic acid exposure where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Mycophenolate?
MediHelp rates the interaction as moderate. Calcium and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing divalent cations may reduce mycophenolate exposure, with the effect most clearly documented for magnesium and aluminum. Calcium carbonate is likely to have a smaller effect, but reduced immunosuppression is a concern in transplant recipients.
How serious is the interaction between Calcium and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours and monitor for signs of rejection or mycophenolic acid exposure where available.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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