Drug interactions
Calcium + Sofosbuvir / velpatasvir
Severity: Moderate
Calcium and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir solubility falls sharply at higher gastric pH, so calcium carbonate antacids can lower its exposure. This may reduce hepatitis C cure rates.
What this interaction means in plain words
Calcium and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antacid-induced rise in gastric pH reduces velpatasvir solubility and absorption.
What to do
Separate sofosbuvir/velpatasvir from antacids by at least 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Calcium and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir solubility falls sharply at higher gastric pH, so calcium carbonate antacids can lower its exposure. This may reduce hepatitis C cure rates.
How serious is the interaction between Calcium and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sofosbuvir/velpatasvir from antacids by at least 4 hours.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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