Drug interactions
Calcium + Squill
Severity: Moderate
Calcium and Squill: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides, and raised serum calcium sharpens the myocardium's sensitivity to these compounds. Hypercalcemia from calcium supplementation, especially parenteral calcium, may provoke digitalis-type arrhythmias.
What this interaction means in plain words
Calcium and Squill can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: increased intracellular calcium potentiates the inotropic and arrhythmogenic actions of cardiac glycosides.
What to do
Avoid giving intravenous calcium to patients taking squill-containing products; if oral calcium is needed, monitor serum calcium and ECG for arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium and Squill, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Squill?
MediHelp rates the interaction as moderate. Calcium and Squill can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Squill contains cardiac glycosides, and raised serum calcium sharpens the myocardium's sensitivity to these compounds. Hypercalcemia from calcium supplementation, especially parenteral calcium, may provoke digitalis-type arrhythmias.
How serious is the interaction between Calcium and Squill?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving intravenous calcium to patients taking squill-containing products; if oral calcium is needed, monitor serum calcium and ECG for arrhythmias.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
