Drug interactions
Calcium chloride + Felodipine
Severity: Moderate
Calcium chloride and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium chloride can transiently reverse the effects of calcium channel blockers, and is used as an antidote in overdose. In routine use, felodipine's antihypertensive effect may be reduced.
What this interaction means in plain words
Calcium chloride and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased extracellular calcium overcomes L-type calcium channel blockade.
What to do
Monitor blood pressure and cardiac status when parenteral calcium is given to patients taking felodipine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Calcium chloride with Felodipine?
MediHelp rates the interaction as moderate. Calcium chloride and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium chloride can transiently reverse the effects of calcium channel blockers, and is used as an antidote in overdose. In routine use, felodipine's antihypertensive effect may be reduced.
How serious is the interaction between Calcium chloride and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and cardiac status when parenteral calcium is given to patients taking felodipine.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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