Drug interactions
Calcium chloride + Levofloxacin
Severity: Moderate
Calcium chloride and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium salts can bind levofloxacin in the gut and reduce its absorption, potentially lowering antibiotic effectiveness. This applies only when both are taken by mouth.
What this interaction means in plain words
Calcium chloride and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of levofloxacin by calcium ions in the gastrointestinal tract, reducing absorption.
What to do
Separate oral levofloxacin from oral calcium by at least 2 hours, taking levofloxacin first. Intravenous calcium does not require separation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Calcium chloride with Levofloxacin?
MediHelp rates the interaction as moderate. Calcium chloride and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium salts can bind levofloxacin in the gut and reduce its absorption, potentially lowering antibiotic effectiveness. This applies only when both are taken by mouth.
How serious is the interaction between Calcium chloride and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral levofloxacin from oral calcium by at least 2 hours, taking levofloxacin first. Intravenous calcium does not require separation.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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