Drug interactions
Calcium chloride + Levothyroxine
Severity: Moderate
Calcium chloride and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium salts bind levothyroxine in the gut and reduce its absorption, which can raise TSH and cause hypothyroid symptoms. The interaction is relevant to oral calcium chloride only.
What this interaction means in plain words
Calcium chloride and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium forms insoluble complexes with levothyroxine in the gastrointestinal tract, reducing absorption.
What to do
Separate oral levothyroxine and calcium by at least 4 hours. Monitor TSH after starting or stopping calcium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium chloride and Levothyroxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Levothyroxine
Frequently asked questions
Can I take Calcium chloride with Levothyroxine?
MediHelp rates the interaction as moderate. Calcium chloride and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium salts bind levothyroxine in the gut and reduce its absorption, which can raise TSH and cause hypothyroid symptoms. The interaction is relevant to oral calcium chloride only.
How serious is the interaction between Calcium chloride and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral levothyroxine and calcium by at least 4 hours. Monitor TSH after starting or stopping calcium.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
