Drug interactions
Calcium chloride + Verapamil
Severity: Moderate
Calcium chloride and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium chloride raises extracellular calcium and can reverse verapamil's hypotensive and negative chronotropic effects. This is used therapeutically in verapamil toxicity but may undermine verapamil therapy if given unintentionally.
What this interaction means in plain words
Calcium chloride and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased extracellular calcium overcomes L-type calcium channel blockade.
What to do
Avoid unnecessary IV calcium in patients relying on verapamil for rate control; monitor heart rate, blood pressure and serum calcium when it is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Calcium chloride with Verapamil?
MediHelp rates the interaction as moderate. Calcium chloride and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium chloride raises extracellular calcium and can reverse verapamil's hypotensive and negative chronotropic effects. This is used therapeutically in verapamil toxicity but may undermine verapamil therapy if given unintentionally.
How serious is the interaction between Calcium chloride and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary IV calcium in patients relying on verapamil for rate control; monitor heart rate, blood pressure and serum calcium when it is required.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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