Drug interactions
Calcium citrate + Levofloxacin
Severity: Moderate
Calcium citrate and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium citrate taken close to oral levofloxacin can reduce levofloxacin absorption and lead to subtherapeutic levels. This could compromise treatment of infection.
What this interaction means in plain words
Calcium citrate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of levofloxacin by calcium in the gut, decreasing absorption.
What to do
Take levofloxacin at least 2 hours before or after calcium citrate supplements.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Calcium citrate with Levofloxacin?
MediHelp rates the interaction as moderate. Calcium citrate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium citrate taken close to oral levofloxacin can reduce levofloxacin absorption and lead to subtherapeutic levels. This could compromise treatment of infection.
How serious is the interaction between Calcium citrate and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take levofloxacin at least 2 hours before or after calcium citrate supplements.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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