Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Chlordiazepoxide-clidinium
Severity: Major
Calcium / magnesium / potassium / sodium oxybates and Chlordiazepoxide-clidinium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates are potent CNS depressants, and combining them with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via GABAergic mechanisms.
What to do
Avoid the combination where possible, choosing a non-sedating alternative to the benzodiazepine. If unavoidable, use minimum doses and monitor closely for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates are potent CNS depressants, and combining them with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, choosing a non-sedating alternative to the benzodiazepine. If unavoidable, use minimum doses and monitor closely for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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