Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Maprotiline
Severity: Major
Calcium / magnesium / potassium / sodium oxybates and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates cause profound CNS and respiratory depression, which can be worsened by sedating antidepressants such as maprotiline. Coma and death have been described with oxybate and other CNS depressants.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid if possible; if both are needed, use the lowest effective doses and monitor closely for sedation and respiratory depression. Counsel the patient not to drive or use alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Maprotiline?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates cause profound CNS and respiratory depression, which can be worsened by sedating antidepressants such as maprotiline. Coma and death have been described with oxybate and other CNS depressants.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are needed, use the lowest effective doses and monitor closely for sedation and respiratory depression. Counsel the patient not to drive or use alcohol.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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