Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Pentazocine
Severity: Contraindicated
Calcium / magnesium / potassium / sodium oxybates and Pentazocine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates are potent CNS depressants, and combining them with an opioid like pentazocine can cause profound sedation, respiratory depression, coma and death. Product labeling warns against concurrent use with other CNS depressants.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Pentazocine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Avoid the combination. If an opioid is unavoidable, use the lowest dose for the shortest duration and monitor consciousness and respiration closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pentazocine
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
- Alvimopan + Pentazocine Major
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Pentazocine?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Pentazocine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants, and combining them with an opioid like pentazocine can cause profound sedation, respiratory depression, coma and death. Product labeling warns against concurrent use with other CNS depressants.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Pentazocine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If an opioid is unavoidable, use the lowest dose for the shortest duration and monitor consciousness and respiration closely.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Olanzapine / samidorphan, Phenelzine, Tranylcypromine. The full list is on the Pentazocine page.
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