Drug interactions
Olanzapine / samidorphan + Pentazocine
Severity: Contraindicated
Olanzapine / samidorphan and Pentazocine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Samidorphan blocks opioid receptors and can reduce pentazocine's analgesic effect. It may also precipitate acute withdrawal in patients who are opioid-dependent.
What this interaction means in plain words
Olanzapine / samidorphan and Pentazocine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Samidorphan antagonizes opioid receptors, opposing the effect of pentazocine.
What to do
Avoid the combination; observe the labeled opioid-free interval (7 days for short-acting, 14 days for long-acting opioids) before starting. Use non-opioid analgesia during treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
- Alvimopan + Pentazocine Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Pentazocine?
MediHelp rates the interaction as contraindicated. Olanzapine / samidorphan and Pentazocine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors and can reduce pentazocine's analgesic effect. It may also precipitate acute withdrawal in patients who are opioid-dependent.
How serious is the interaction between Olanzapine / samidorphan and Pentazocine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; observe the labeled opioid-free interval (7 days for short-acting, 14 days for long-acting opioids) before starting. Use non-opioid analgesia during treatment.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Phenelzine, Tranylcypromine. The full list is on the Pentazocine page.
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