Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Thioridazine
Severity: Major
Calcium / magnesium / potassium / sodium oxybates and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates and thioridazine both depress the central nervous system, so together they may produce profound sedation, respiratory depression, coma or death. Oxybate labeling advises against concurrent use of CNS depressants.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via GABA-B/GHB receptor activity and phenothiazine sedation.
What to do
Avoid if possible; if needed, use the lowest doses for the shortest time and monitor sedation and breathing. Consider lowering or withholding oxybate doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Thioridazine?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates and thioridazine both depress the central nervous system, so together they may produce profound sedation, respiratory depression, coma or death. Oxybate labeling advises against concurrent use of CNS depressants.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, use the lowest doses for the shortest time and monitor sedation and breathing. Consider lowering or withholding oxybate doses.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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