Drug interactions
Canagliflozin-metformin + Candesartan
Severity: Moderate
Canagliflozin-metformin and Candesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan can increase serum potassium, and canagliflozin may add to this effect in patients with reduced renal function. Volume depletion from canagliflozin can also worsen renal function on an ARB.
What this interaction means in plain words
Canagliflozin-metformin and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Candesartan belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade reduces aldosterone-driven potassium excretion, with possible additive effects.
What to do
Monitor potassium, creatinine and volume status after initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Canagliflozin-metformin with Candesartan?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Candesartan can increase serum potassium, and canagliflozin may add to this effect in patients with reduced renal function. Volume depletion from canagliflozin can also worsen renal function on an ARB.
How serious is the interaction between Canagliflozin-metformin and Candesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, creatinine and volume status after initiation and dose changes.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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