Drug interactions
Canagliflozin-metformin + Chlorpropamide
Severity: Moderate
Canagliflozin-metformin and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin plus metformin added to a sulfonylurea such as chlorpropamide increases the chance of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged, especially in older adults or those with renal impairment.
What this interaction means in plain words
Canagliflozin-metformin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Chlorpropamide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with the sulfonylurea driving insulin secretion independently of glucose.
What to do
Consider lowering the chlorpropamide dose when starting canagliflozin-metformin and monitor blood glucose. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Canagliflozin-metformin with Chlorpropamide?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin plus metformin added to a sulfonylurea such as chlorpropamide increases the chance of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged, especially in older adults or those with renal impairment.
How serious is the interaction between Canagliflozin-metformin and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the chlorpropamide dose when starting canagliflozin-metformin and monitor blood glucose. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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