Drug interactions
Canagliflozin-metformin + Clozapine
Severity: Moderate
Canagliflozin-metformin and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine often causes weight gain, insulin resistance, hyperglycemia and sometimes diabetic ketoacidosis. This can work against the glucose-lowering effect of the antidiabetic combination and increase the dose requirement.
What this interaction means in plain words
Canagliflozin-metformin and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Clozapine belongs to Central Nervous System.
Why it happens
Clozapine promotes insulin resistance and weight gain and may impair beta-cell function, opposing antidiabetic drug effects.
What to do
Monitor fasting glucose and HbA1c regularly and intensify antidiabetic therapy as required. Review metabolic parameters at baseline and periodically during clozapine treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Canagliflozin-metformin with Clozapine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine often causes weight gain, insulin resistance, hyperglycemia and sometimes diabetic ketoacidosis. This can work against the glucose-lowering effect of the antidiabetic combination and increase the dose requirement.
How serious is the interaction between Canagliflozin-metformin and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly and intensify antidiabetic therapy as required. Review metabolic parameters at baseline and periodically during clozapine treatment.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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