Drug interactions
Canagliflozin-metformin + Cyanocobalamin
Severity: Minor
Canagliflozin-metformin and Cyanocobalamin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term metformin use can reduce vitamin B12 absorption and lower serum B12 levels, and may lead to deficiency and neuropathy or anemia. Cyanocobalamin supplementation counters this effect rather than being harmed by it.
What this interaction means in plain words
Canagliflozin-metformin and Cyanocobalamin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Cyanocobalamin belongs to Miscellaneous.
Why it happens
Metformin interferes with calcium-dependent ileal absorption of the vitamin B12-intrinsic factor complex.
What to do
Check vitamin B12 periodically in long-term metformin users, particularly those with anemia or neuropathy. Supplement B12 if levels are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Canagliflozin-metformin with Cyanocobalamin?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Cyanocobalamin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term metformin use can reduce vitamin B12 absorption and lower serum B12 levels, and may lead to deficiency and neuropathy or anemia. Cyanocobalamin supplementation counters this effect rather than being harmed by it.
How serious is the interaction between Canagliflozin-metformin and Cyanocobalamin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check vitamin B12 periodically in long-term metformin users, particularly those with anemia or neuropathy. Supplement B12 if levels are low.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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