Drug interactions
Canagliflozin-metformin + Deflazacort
Severity: Moderate
Canagliflozin-metformin and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a systemic corticosteroid that can raise blood glucose and reduce the effect of antidiabetic drugs. Glycemic control may deteriorate during treatment and improve when the steroid is reduced or stopped.
What this interaction means in plain words
Canagliflozin-metformin and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Deflazacort belongs to Miscellaneous.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic gluconeogenesis oppose antidiabetic effects.
What to do
Monitor blood glucose when deflazacort is started or the dose is changed, and adjust diabetes therapy as needed. Reduce antidiabetic doses again if the steroid is stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Deflazacort?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a systemic corticosteroid that can raise blood glucose and reduce the effect of antidiabetic drugs. Glycemic control may deteriorate during treatment and improve when the steroid is reduced or stopped.
How serious is the interaction between Canagliflozin-metformin and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when deflazacort is started or the dose is changed, and adjust diabetes therapy as needed. Reduce antidiabetic doses again if the steroid is stopped to avoid hypoglycemia.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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