Drug interactions
Canagliflozin-metformin + Drospirenone
Severity: Minor
Canagliflozin-metformin and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium. Canagliflozin has been associated with small potassium increases, particularly in renal impairment, so hyperkalemia is possible though uncommon in healthy women.
What this interaction means in plain words
Canagliflozin-metformin and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Drospirenone belongs to Endocrine.
Why it happens
Drospirenone blocks mineralocorticoid receptors, decreasing renal potassium excretion, an effect potentially additive with canagliflozin.
What to do
Check serum potassium in the first cycle in patients with renal impairment or other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Drospirenone
Frequently asked questions
Can I take Canagliflozin-metformin with Drospirenone?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium. Canagliflozin has been associated with small potassium increases, particularly in renal impairment, so hyperkalemia is possible though uncommon in healthy women.
How serious is the interaction between Canagliflozin-metformin and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle in patients with renal impairment or other potassium-raising drugs.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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