Drug interactions
Canagliflozin-metformin + Eprosartan
Severity: Moderate
Canagliflozin-metformin and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can raise serum potassium, and canagliflozin may contribute slightly. Combined use with an SGLT2 inhibitor also may cause volume depletion and a fall in renal function.
What this interaction means in plain words
Canagliflozin-metformin and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Eprosartan belongs to Cardiovascular.
Why it happens
ARB-mediated reduction in aldosterone lowers renal potassium excretion, and combined hemodynamic effects can reduce glomerular filtration.
What to do
Monitor potassium, blood pressure and renal function after initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Canagliflozin-metformin with Eprosartan?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can raise serum potassium, and canagliflozin may contribute slightly. Combined use with an SGLT2 inhibitor also may cause volume depletion and a fall in renal function.
How serious is the interaction between Canagliflozin-metformin and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, blood pressure and renal function after initiation and dose changes.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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