Drug interactions
Canagliflozin-metformin + Givinostat
Severity: Moderate
Canagliflozin-metformin and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat weakly inhibits transporters involved in renal secretion and may modestly increase exposure to metformin. Higher metformin levels may raise the risk of adverse effects including lactic acidosis in susceptible patients.
What this interaction means in plain words
Canagliflozin-metformin and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Givinostat belongs to Miscellaneous.
Why it happens
Inhibition of renal cation transporters may reduce metformin tubular secretion.
What to do
Monitor renal function and for metformin adverse effects, and consider reducing the metformin dose if tolerability or renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Canagliflozin-metformin with Givinostat?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat weakly inhibits transporters involved in renal secretion and may modestly increase exposure to metformin. Higher metformin levels may raise the risk of adverse effects including lactic acidosis in susceptible patients.
How serious is the interaction between Canagliflozin-metformin and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for metformin adverse effects, and consider reducing the metformin dose if tolerability or renal function worsens.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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