Drug interactions
Canagliflozin-metformin + Imipramine
Severity: Minor
Canagliflozin-metformin and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have occasionally been linked to altered glycemic control and hypoglycemia in diabetic patients. Any effect with metformin-based therapy is small and inconsistent.
What this interaction means in plain words
Canagliflozin-metformin and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Possible modest additive glucose-lowering effect; the mechanism is not well established.
What to do
No routine action is needed; check blood glucose if symptoms of hypoglycemia or changes in control occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Imipramine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have occasionally been linked to altered glycemic control and hypoglycemia in diabetic patients. Any effect with metformin-based therapy is small and inconsistent.
How serious is the interaction between Canagliflozin-metformin and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check blood glucose if symptoms of hypoglycemia or changes in control occur.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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