Drug interactions
Canagliflozin-metformin + Isocarboxazid
Severity: Moderate
Canagliflozin-metformin and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance insulin sensitivity and lower blood glucose, which may add to the effect of canagliflozin-metformin and cause hypoglycemia. Clinically significant episodes are uncommon but have been described with MAOIs and antidiabetic drugs.
What this interaction means in plain words
Canagliflozin-metformin and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibition may improve insulin sensitivity and alter glucose homeostasis, producing additive glucose lowering.
What to do
Monitor blood glucose when starting or stopping isocarboxazid. Reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Isocarboxazid?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance insulin sensitivity and lower blood glucose, which may add to the effect of canagliflozin-metformin and cause hypoglycemia. Clinically significant episodes are uncommon but have been described with MAOIs and antidiabetic drugs.
How serious is the interaction between Canagliflozin-metformin and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping isocarboxazid. Reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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