Drug interactions
Canagliflozin-metformin + Levonorgestrel
Severity: Minor
Canagliflozin-metformin and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly reduce glucose tolerance and insulin sensitivity. The effect with low-dose levonorgestrel is usually small and seldom alters glycemic control.
What this interaction means in plain words
Canagliflozin-metformin and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Levonorgestrel belongs to Endocrine.
Why it happens
Progestogenic activity may modestly increase insulin resistance, opposing glucose-lowering drugs.
What to do
Monitor blood glucose when starting hormonal contraception. Adjust antidiabetic therapy only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Canagliflozin-metformin with Levonorgestrel?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly reduce glucose tolerance and insulin sensitivity. The effect with low-dose levonorgestrel is usually small and seldom alters glycemic control.
How serious is the interaction between Canagliflozin-metformin and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting hormonal contraception. Adjust antidiabetic therapy only if control worsens.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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