Drug interactions
Canagliflozin-metformin + Lisinopril
Severity: Moderate
Canagliflozin-metformin and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can raise serum potassium and may improve insulin sensitivity, occasionally lowering blood glucose. Combined with canagliflozin-related volume depletion, they may impair renal function, increasing metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Canagliflozin-metformin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
ACE inhibition reduces aldosterone and efferent arteriolar tone, raising potassium and lowering GFR, particularly with SGLT2-inhibitor volume loss.
What to do
Monitor serum potassium, creatinine/eGFR and blood glucose after initiation and dose changes. Reduce or stop metformin if eGFR drops substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Lisinopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Canagliflozin-metformin with Lisinopril?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can raise serum potassium and may improve insulin sensitivity, occasionally lowering blood glucose. Combined with canagliflozin-related volume depletion, they may impair renal function, increasing metformin accumulation and lactic acidosis risk.
How serious is the interaction between Canagliflozin-metformin and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine/eGFR and blood glucose after initiation and dose changes. Reduce or stop metformin if eGFR drops substantially.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
