Drug interactions
Canagliflozin-metformin + Nateglinide
Severity: Moderate
Canagliflozin-metformin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide stimulates insulin secretion, so adding it to canagliflozin and metformin can increase the risk of hypoglycemia. The effect is usually milder than with sulfonylureas because nateglinide acts briefly.
What this interaction means in plain words
Canagliflozin-metformin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with nateglinide stimulating insulin secretion from pancreatic beta cells.
What to do
Monitor blood glucose after initiating the combination and lower the nateglinide dose if hypoglycemia occurs. Advise patients to take nateglinide only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Nateglinide?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide stimulates insulin secretion, so adding it to canagliflozin and metformin can increase the risk of hypoglycemia. The effect is usually milder than with sulfonylureas because nateglinide acts briefly.
How serious is the interaction between Canagliflozin-metformin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after initiating the combination and lower the nateglinide dose if hypoglycemia occurs. Advise patients to take nateglinide only with meals.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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