Drug interactions
Canagliflozin-metformin + Nelfinavir
Severity: Moderate
Canagliflozin-metformin and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir and other protease inhibitors have been linked to insulin resistance and hyperglycemia. Glycemic control on canagliflozin-metformin may worsen.
What this interaction means in plain words
Canagliflozin-metformin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitors can impair insulin-mediated glucose uptake and cause insulin resistance, which opposes the glucose-lowering effect of the antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c after nelfinavir is started or changed. Increase antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Nelfinavir?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir and other protease inhibitors have been linked to insulin resistance and hyperglycemia. Glycemic control on canagliflozin-metformin may worsen.
How serious is the interaction between Canagliflozin-metformin and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after nelfinavir is started or changed. Increase antidiabetic therapy as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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