Drug interactions
Canagliflozin-metformin + Nilotinib
Severity: Moderate
Canagliflozin-metformin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is associated with hyperglycemia in some patients, which may reduce the effectiveness of antidiabetic therapy. Glucose elevations are generally manageable.
What this interaction means in plain words
Canagliflozin-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib has an independent hyperglycemic effect whose mechanism is not fully established.
What to do
Monitor blood glucose during nilotinib therapy and intensify the antidiabetic regimen if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Nilotinib?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is associated with hyperglycemia in some patients, which may reduce the effectiveness of antidiabetic therapy. Glucose elevations are generally manageable.
How serious is the interaction between Canagliflozin-metformin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during nilotinib therapy and intensify the antidiabetic regimen if needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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