Drug interactions
Canagliflozin-metformin + Ofloxacin
Severity: Moderate
Canagliflozin-metformin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin can cause hypoglycemia or hyperglycemia in patients taking glucose-lowering drugs. Severe cases, mainly with sulfonylureas or insulin, have been reported.
What this interaction means in plain words
Canagliflozin-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, producing dysglycemia.
What to do
Monitor blood glucose during the antibiotic course and counsel the patient about symptoms of dysglycemia. Consider another antibiotic if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Canagliflozin-metformin with Ofloxacin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin can cause hypoglycemia or hyperglycemia in patients taking glucose-lowering drugs. Severe cases, mainly with sulfonylureas or insulin, have been reported.
How serious is the interaction between Canagliflozin-metformin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and counsel the patient about symptoms of dysglycemia. Consider another antibiotic if glucose becomes unstable.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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