Drug interactions
Canagliflozin-metformin + Paroxetine
Severity: Minor
Canagliflozin-metformin and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as paroxetine may enhance glucose lowering and occasionally cause hypoglycemia in diabetic patients, whereas paroxetine can also cause weight gain. Effects on glucose are variable and usually modest.
What this interaction means in plain words
Canagliflozin-metformin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Paroxetine belongs to Central Nervous System.
Why it happens
Serotonergic effects may alter insulin sensitivity and glucose metabolism; the mechanism is not well established.
What to do
Monitor blood glucose when paroxetine is started or stopped and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Paroxetine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as paroxetine may enhance glucose lowering and occasionally cause hypoglycemia in diabetic patients, whereas paroxetine can also cause weight gain. Effects on glucose are variable and usually modest.
How serious is the interaction between Canagliflozin-metformin and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when paroxetine is started or stopped and adjust antidiabetic therapy if needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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