Drug interactions
Canagliflozin-metformin + Phenelzine
Severity: Moderate
Canagliflozin-metformin and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance insulin sensitivity and lower blood glucose, which may cause hypoglycemia with antidiabetic drugs. The effect is more established with insulin and sulfonylureas than with metformin.
What this interaction means in plain words
Canagliflozin-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition may increase insulin sensitivity, producing additive glucose lowering.
What to do
Monitor blood glucose when phenelzine is started or stopped and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Phenelzine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance insulin sensitivity and lower blood glucose, which may cause hypoglycemia with antidiabetic drugs. The effect is more established with insulin and sulfonylureas than with metformin.
How serious is the interaction between Canagliflozin-metformin and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when phenelzine is started or stopped and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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