Drug interactions
Canagliflozin-metformin + Promethazine
Severity: Minor
Canagliflozin-metformin and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine antihistamine, may raise blood glucose, especially at higher doses. The effect is usually small and temporary.
What this interaction means in plain words
Canagliflozin-metformin and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Phenothiazine effects may reduce insulin sensitivity or secretion; the mechanism is not firmly established.
What to do
Monitor glucose during prolonged or high-dose use and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Canagliflozin-metformin with Promethazine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine, a phenothiazine antihistamine, may raise blood glucose, especially at higher doses. The effect is usually small and temporary.
How serious is the interaction between Canagliflozin-metformin and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose during prolonged or high-dose use and adjust antidiabetic therapy if control worsens.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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