Drug interactions
Canagliflozin-metformin + Selegiline
Severity: Minor
Canagliflozin-metformin and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established clinical interaction is described between metformin and selegiline. Monoamine oxidase inhibitors have been reported to affect glucose levels, so glycemic changes are possible, but the evidence is weak.
What this interaction means in plain words
Canagliflozin-metformin and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
Not established; MAO inhibitors may influence glucose homeostasis and insulin sensitivity.
What to do
No dose change is usually needed; monitor blood glucose when selegiline is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Selegiline?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established clinical interaction is described between metformin and selegiline. Monoamine oxidase inhibitors have been reported to affect glucose levels, so glycemic changes are possible, but the evidence is weak.
How serious is the interaction between Canagliflozin-metformin and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood glucose when selegiline is started or stopped.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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