Drug interactions
Canagliflozin-metformin + Triamterene
Severity: Moderate
Canagliflozin-metformin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a potassium-sparing diuretic that frequently causes hyperkalemia, and canagliflozin may add slightly to this. Volume depletion from both drugs can also impair renal function and raise metformin exposure.
What this interaction means in plain words
Canagliflozin-metformin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene blocks epithelial sodium channels, reducing potassium excretion, with additive volume and potassium effects from canagliflozin.
What to do
Monitor serum potassium and renal function regularly, especially in CKD. Stop or reduce triamterene if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Canagliflozin-metformin with Triamterene?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene is a potassium-sparing diuretic that frequently causes hyperkalemia, and canagliflozin may add slightly to this. Volume depletion from both drugs can also impair renal function and raise metformin exposure.
How serious is the interaction between Canagliflozin-metformin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly, especially in CKD. Stop or reduce triamterene if hyperkalemia develops.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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