Drug interactions
Canagliflozin-metformin + Valsartan
Severity: Moderate
Canagliflozin-metformin and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan reduces aldosterone-mediated potassium excretion and can cause hyperkalemia, especially in CKD or diabetes. Canagliflozin may contribute slightly, and combined volume effects may affect renal function.
What this interaction means in plain words
Canagliflozin-metformin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Valsartan belongs to Cardiovascular.
Why it happens
Additive effects on potassium homeostasis and renal hemodynamics.
What to do
Monitor serum potassium and creatinine at baseline and periodically. Correct volume depletion and adjust doses if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Canagliflozin-metformin with Valsartan?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan reduces aldosterone-mediated potassium excretion and can cause hyperkalemia, especially in CKD or diabetes. Canagliflozin may contribute slightly, and combined volume effects may affect renal function.
How serious is the interaction between Canagliflozin-metformin and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine at baseline and periodically. Correct volume depletion and adjust doses if hyperkalemia develops.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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