Drug interactions
Canagliflozin-metformin + Vandetanib
Severity: Moderate
Canagliflozin-metformin and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits OCT2-mediated uptake and may reduce renal secretion of metformin. This can increase metformin exposure and the risk of adverse effects including lactic acidosis.
What this interaction means in plain words
Canagliflozin-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Inhibition of renal OCT2 transport by vandetanib reduces metformin clearance.
What to do
Monitor renal function, glycemic control and signs of metformin toxicity, and reduce the metformin dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Vandetanib?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits OCT2-mediated uptake and may reduce renal secretion of metformin. This can increase metformin exposure and the risk of adverse effects including lactic acidosis.
How serious is the interaction between Canagliflozin-metformin and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, glycemic control and signs of metformin toxicity, and reduce the metformin dose if adverse effects develop.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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