Drug interactions
Candesartan + Enoxaparin
Severity: Moderate
Candesartan and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress adrenal aldosterone production, which may cause hyperkalemia. With an ARB, which also reduces aldosterone effect, the risk of elevated potassium increases, particularly in diabetes or renal impairment.
What this interaction means in plain words
Candesartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis adds to ARB blockade of angiotensin II-driven aldosterone effects.
What to do
Monitor serum potassium, especially in renal impairment or if therapy lasts more than a few days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Candesartan with Enoxaparin?
MediHelp rates the interaction as moderate. Candesartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress adrenal aldosterone production, which may cause hyperkalemia. With an ARB, which also reduces aldosterone effect, the risk of elevated potassium increases, particularly in diabetes or renal impairment.
How serious is the interaction between Candesartan and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially in renal impairment or if therapy lasts more than a few days.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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