Drug interactions
Candesartan + Eprosartan-hydrochlorothiazide
Severity: Major
Candesartan and Eprosartan-hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both products contain or act as angiotensin II receptor blockers, so giving them together duplicates therapy. Dual blockade of the renin-angiotensin system does not add meaningful benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
What this interaction means in plain words
Candesartan and Eprosartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan belongs to Cardiovascular; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade producing additive hypotension, reduced glomerular filtration pressure and reduced aldosterone-mediated potassium excretion.
What to do
Avoid combining two angiotensin receptor blockers and use a single agent at an optimized dose. If both have been given, stop one and check potassium and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Candesartan and Eprosartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both products contain or act as angiotensin II receptor blockers, so giving them together duplicates therapy. Dual blockade of the renin-angiotensin system does not add meaningful benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Candesartan and Eprosartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two angiotensin receptor blockers and use a single agent at an optimized dose. If both have been given, stop one and check potassium and creatinine.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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