Drug interactions
Candesartan + Lisinopril
Severity: Major
Candesartan and Lisinopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dual renin-angiotensin system blockade with lisinopril and candesartan raises the risk of hypotension, hyperkalemia and renal impairment. Benefit is limited to select heart failure cases.
What this interaction means in plain words
Candesartan and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan belongs to Cardiovascular; Lisinopril belongs to Cardiovascular.
Why it happens
Additive blockade of the renin-angiotensin-aldosterone system at two levels.
What to do
Avoid routine use. If deliberately combined, monitor potassium, creatinine and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Lisinopril?
MediHelp rates the interaction as major. Candesartan and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dual renin-angiotensin system blockade with lisinopril and candesartan raises the risk of hypotension, hyperkalemia and renal impairment. Benefit is limited to select heart failure cases.
How serious is the interaction between Candesartan and Lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine use. If deliberately combined, monitor potassium, creatinine and blood pressure.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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