Drug interactions
Candesartan-hydrochlorothiazide + Carvedilol
Severity: Moderate
Candesartan-hydrochlorothiazide and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol combined with an ARB and a thiazide gives additive blood pressure lowering and may cause hypotension, dizziness or bradycardia. Carvedilol can also affect glucose and potassium handling.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through alpha/beta-blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure, heart rate and serum potassium when starting or titrating. Avoid use during pregnancy because of the ARB.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Carvedilol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol combined with an ARB and a thiazide gives additive blood pressure lowering and may cause hypotension, dizziness or bradycardia. Carvedilol can also affect glucose and potassium handling.
How serious is the interaction between Candesartan-hydrochlorothiazide and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when starting or titrating. Avoid use during pregnancy because of the ARB.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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