Drug interactions
Candesartan-hydrochlorothiazide + Choline magnesium trisalicylate
Severity: Moderate
Candesartan-hydrochlorothiazide and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at the doses given for this product can weaken the antihypertensive effect of candesartan and hydrochlorothiazide. In elderly or volume-depleted patients the combination of ARB, diuretic and salicylate may impair renal function.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing ARB and diuretic effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated. Consider a non-NSAID analgesic if blood pressure control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at the doses given for this product can weaken the antihypertensive effect of candesartan and hydrochlorothiazide. In elderly or volume-depleted patients the combination of ARB, diuretic and salicylate may impair renal function.
How serious is the interaction between Candesartan-hydrochlorothiazide and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated. Consider a non-NSAID analgesic if blood pressure control worsens.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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