Drug interactions
Candesartan-hydrochlorothiazide + Citalopram
Severity: Moderate
Candesartan-hydrochlorothiazide and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and SSRIs can cause hyponatremia, and the combination increases the risk, especially in older adults. Thiazide-induced hypokalemia or hypomagnesemia may also add to citalopram's QT-prolonging effect.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Citalopram belongs to Central Nervous System.
Why it happens
Additive hyponatremia through diuretic sodium loss and SSRI-related SIADH, plus electrolyte-related QT risk.
What to do
Check serum sodium, potassium and magnesium at baseline and after starting. Watch for confusion, nausea or falls and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Citalopram?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and SSRIs can cause hyponatremia, and the combination increases the risk, especially in older adults. Thiazide-induced hypokalemia or hypomagnesemia may also add to citalopram's QT-prolonging effect.
How serious is the interaction between Candesartan-hydrochlorothiazide and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium, potassium and magnesium at baseline and after starting. Watch for confusion, nausea or falls and correct electrolyte abnormalities.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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