Drug interactions
Candesartan-hydrochlorothiazide + Cortisone
Severity: Moderate
Candesartan-hydrochlorothiazide and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids promote renal potassium loss and, together with thiazide diuretics, can cause additive hypokalemia. Cortisone also has mineralocorticoid activity that causes sodium and fluid retention, which can oppose the antihypertensive effect.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting and mineralocorticoid-mediated sodium retention.
What to do
Monitor serum potassium and blood pressure, and replace potassium if needed, especially with prolonged or high-dose steroid therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Cortisone?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote renal potassium loss and, together with thiazide diuretics, can cause additive hypokalemia. Cortisone also has mineralocorticoid activity that causes sodium and fluid retention, which can oppose the antihypertensive effect.
How serious is the interaction between Candesartan-hydrochlorothiazide and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and replace potassium if needed, especially with prolonged or high-dose steroid therapy.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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