Drug interactions
Candesartan-hydrochlorothiazide + Cosyntropin
Severity: Minor
Candesartan-hydrochlorothiazide and Cosyntropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cosyntropin stimulates adrenal steroid release, which can cause potassium loss and fluid retention. With a thiazide this could add to hypokalemia, but a single diagnostic dose has little practical impact.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Cosyntropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Cosyntropin belongs to Musculoskeletal.
Why it happens
Adrenocortical stimulation increases mineralocorticoid and glucocorticoid effects that add to thiazide potassium loss.
What to do
No routine action is needed for a single diagnostic dose; check potassium if repeated dosing is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Cosyntropin
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Cosyntropin?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Cosyntropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cosyntropin stimulates adrenal steroid release, which can cause potassium loss and fluid retention. With a thiazide this could add to hypokalemia, but a single diagnostic dose has little practical impact.
How serious is the interaction between Candesartan-hydrochlorothiazide and Cosyntropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for a single diagnostic dose; check potassium if repeated dosing is used.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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