Drug interactions
Candesartan-hydrochlorothiazide + Cyclosporine
Severity: Moderate
Candesartan-hydrochlorothiazide and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine with hydrochlorothiazide can increase uric acid and impair renal function. Together with candesartan, there is added risk of hyperkalemia and reduced renal function.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic, hyperuricemic and potassium-retaining effects.
What to do
Monitor creatinine, potassium, sodium and uric acid, and cyclosporine trough levels. Adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Cyclosporine?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine with hydrochlorothiazide can increase uric acid and impair renal function. Together with candesartan, there is added risk of hyperkalemia and reduced renal function.
How serious is the interaction between Candesartan-hydrochlorothiazide and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium, sodium and uric acid, and cyclosporine trough levels. Adjust doses as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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