Drug interactions
Candesartan-hydrochlorothiazide + Dichlorphenamide
Severity: Moderate
Candesartan-hydrochlorothiazide and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that promotes urinary potassium loss and metabolic acidosis. With a thiazide, the risk of significant hypokalemia increases.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and thiazide action.
What to do
Monitor serum potassium and bicarbonate regularly, and supplement potassium if required. The ARB component offsets potassium loss only partly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Candesartan-hydrochlorothiazide and Dichlorphenamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Dichlorphenamide?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that promotes urinary potassium loss and metabolic acidosis. With a thiazide, the risk of significant hypokalemia increases.
How serious is the interaction between Candesartan-hydrochlorothiazide and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly, and supplement potassium if required. The ARB component offsets potassium loss only partly.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
