Drug interactions
Candesartan-hydrochlorothiazide + Fenoprofen
Severity: Major
Candesartan-hydrochlorothiazide and Fenoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can reduce the antihypertensive effect of candesartan and hydrochlorothiazide and increase the risk of renal impairment, particularly in older or volume-depleted patients. Hyperkalemia may also occur.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, counteracting the diuretic and ARB and adding to renal hemodynamic stress.
What to do
Avoid combining where possible, or use the lowest effective NSAID dose for a short course. Monitor blood pressure, renal function and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Fenoprofen?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenoprofen can reduce the antihypertensive effect of candesartan and hydrochlorothiazide and increase the risk of renal impairment, particularly in older or volume-depleted patients. Hyperkalemia may also occur.
How serious is the interaction between Candesartan-hydrochlorothiazide and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or use the lowest effective NSAID dose for a short course. Monitor blood pressure, renal function and potassium.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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