Drug interactions
Candesartan-hydrochlorothiazide + Fentanyl
Severity: Minor
Candesartan-hydrochlorothiazide and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl can cause hypotension and may promote antidiuretic hormone release, which could blunt the diuretic effect. Additive hypotension with antihypertensives can occur, especially around anesthesia.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Opioid-related vasodilation and sympatholysis add to the antihypertensive effect; opioid-induced ADH release may reduce diuresis.
What to do
Monitor blood pressure and fluid status when fentanyl is started or the dose increased. Watch for orthostatic hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Fentanyl?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl can cause hypotension and may promote antidiuretic hormone release, which could blunt the diuretic effect. Additive hypotension with antihypertensives can occur, especially around anesthesia.
How serious is the interaction between Candesartan-hydrochlorothiazide and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and fluid status when fentanyl is started or the dose increased. Watch for orthostatic hypotension.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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