Drug interactions
Candesartan-hydrochlorothiazide + Formoterol
Severity: Moderate
Candesartan-hydrochlorothiazide and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium by moving it into cells, and hydrochlorothiazide adds renal potassium loss. The combined hypokalemia can promote arrhythmias, especially in patients with severe asthma or COPD or with hypoxia.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Formoterol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2-mediated cellular potassium uptake and thiazide-induced urinary potassium loss.
What to do
Monitor serum potassium in patients on high-dose or frequent formoterol alongside the thiazide. Correct hypokalemia and use the lowest effective bronchodilator dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Formoterol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol can lower serum potassium by moving it into cells, and hydrochlorothiazide adds renal potassium loss. The combined hypokalemia can promote arrhythmias, especially in patients with severe asthma or COPD or with hypoxia.
How serious is the interaction between Candesartan-hydrochlorothiazide and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on high-dose or frequent formoterol alongside the thiazide. Correct hypokalemia and use the lowest effective bronchodilator dose.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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